BOL-148 is one of the non-psychoactive metabolites of lysergic acid diethylamide (commonly known as LSD) and it may be the component that helps with Migraine/Cluster Headaches.
I'm just going to dump a few other resources here as I don't have time to do a proper bit of research and write it up. If you find more useful resources for Migraine suffers please feel free to add them in a comment.
BOL-148 Research Page
Beckley Foundation, Oxford
Cluserbusters: 501(c)(3) non-profit research and educational organization (see their Links page)
Entheogen biopharmaceutical (has BOL-148 clinical trials going)